Estrogen is
a hormone which is mainly associated with females. Men also produces Estrogen,
but Higher levels of estrogen is produced by females. Although it is present in
smaller amounts, yet it plays prominent role maintaining health.
Gender related differences is shown by Type
2 diabetes. It was found that There is reduced incidence of occurring of
type 2 diabetes in premenopausal women.
Estrogen
acts by improving insulin sensitivity and by suppressing Gluconeogenesis. Estrogen
role in controlling glucose homeostasis had given profound of understand
diabetes, obesity and interventions of potential diet.
Lowered
Insulin resistance and plasma glucose levels have observed in clinical trails
of estrogen Replacement therapy in postmenopausal women. This is because deficiency
of estrogen or impaired estrogen signaling is found to be associated with fault
in regulation of metabolic homeostasis and insulin resistance which results in
the development of type 2 diabetes.
As we
said premenopausal women are less prone to incidence of type 2 diabetes than
with age -equivalent men, but after menopause this advantage in women will disappear
with glucose homeostasis as a result of reduced estrogen levels in the body.
Estrogen
with potential effect of reducing the occurring of type 2 diabetes causes risk
of breast cancer or stroke as side effects of estrogen therapy. But development
of targeted estrogens will mimic the therapeutic benefits without any side
effects.
Estrogen
reduces the risk of developing type 2 diabetes via transcription factor FOXO-1, which
increases the insulin resistance and Suppresses Gluconeogenesis.
FOXO-1
plays important role in regulating glucose production via insulin signaling and
it is a key component of insulin signaling pathway with regulates cellular
growth, differentiation and metabolism.
Hepatic
Glucose production is suppressed by Estrogen through activation of estrogen receptor
signaling which is independent of receptor substrates Irs1 and Irs2
of insulin which had given a important mechanism for estrogen in regulation of
glucose homeostasis.
By the
development of novel selective ligands through direct target estrogen receptors
prevent type 2 diabetes, cardiovascular disease and Obesity with rising
abnormal sexual characteristics and breast cancer.
Fundamental
understand of dietary interventions can play a crucial role in controlling
weight gain, glucose levels and related harmful diseases.
Diabetes and menopause are a twin challenge. What should you do?
ReplyDelete- Eating healthy foods and regular exercise and physical activity.
- Check your blood sugar level frequently.
- Ask your doctor about adjusting your diabetes treatment.
- Learn more about menopausal symptoms.
Diabetes Destroyer | Destructeur De Diabète
Thanks informative post. Thanks Lucy.
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